Background: Chronic lymphocytic leukemia (CLL) is characterized by a heterogeneous clinical course, ranging from stable to more aggressive disease. CRP is a sensitive, inexpensive and routinely available biomarker used for clinical diagnosis of acute and chronic inflammation. Methods: A total of 86 consecutive treatment of patients with CLL and a control group comprised of apparently healthy individuals attending for periodic health examinations. Results: The mean CRP level of patients with CLL was 59.377 mg/dL, high-CRP levels (109.83 mg/dL) whereas low-CRP values (3.91 mg/dL). Conclusions: Markedly elevated levels of CRP was observed at the baseline stage in CLL patients, indicating significant inflammation and potential infection burden prior to chemotherapy initiation.