Evaluation of phytochemicals components, antioxidant and antibacterial activities were performed for the leaves, fruits and flowers of Syrian plant CrataegusazarolusL.(C. azarolus) from Rosaceaefamily.C. azarolus L. extracts are used traditionally for various medicinal purposes, the use of both seeds and leaves for intestinal inflammation, weight loss and intestinal gas. They also treat narrowed arteries, and patients with diabetes. The plant was collected from Assal Al-Ward in Kalamoon Mountains. Leaves, fruits and flowers were dried, powdered and dissolved in ethanol. Phytochemical components were identified with liquid chromatography couple with mass spectrophotometry (LC/MS/MS). Antioxidant activity was evaluated using DPPH radical scavenging and Fe2+ chelating activity assays. Antibacterial activity against some bacteria (Staphylococcus aureus,Salmonella typhi, Klebsiella pneumonia, Escherichia coli, and Pseudomonas aeruginosa.) was identified using disk diffusion method, and then minimum inhibitory concentration (MIC) and minimum bactericidal concentration (MBC) were calculated. Phytochemical compounds with medical relevance were identified. Compounds like chlorogenic acid, procyanidin and Catechine were found in extracts of all parts of plant, while Kaempferol-3-O-(2G-α-L-rhamnosyl)-rutinoside was found in flowers and fruits extracts, in addition, the extracts of flowers and leaves are characterized by the presence of Quercetin rutinoside and Dideoxyhexopyranosiderespectively.kaempferol were found in relatively high amounts exerting antioxidant and antibacterial activities. Highest antioxidant activity was shown with flowers extract with IC50 values of 0.021 ± 0.001 and 0.025 ±0.008 for DPPH assay and Fe2+ chelating assay respectively. Flowers extract showed highest activity against all tested bacteria (except Pseudomonas aeruginosa)with inhibition diameter (ID) ranging from 11.6±0.3 mm to 19.7±0.2 mm. and according to MIC and MBC results, Staphylococcus aureus and Salmonella typhi are more sensitivity than other bacteria to all extracts of plant parts at concentration 4 and 8 mg/ml. According to our observation, extracts of C. azarolusL. plant (especially flower extract) area possible source of beneficial medicinally valuable components that can treat diseases related to tested bacterial organisms and oxidative stress.