The research includes the preparation of a new lipophilic base derived from the condensation of sulfonic acid with 4-hydroxybenzaldehyde and reacting the product with some binary metal salts (Mn, Co, Ni, Cu, Cd, Zn, Pt, Hg). The biological study was conducted against two types of Gram-positive and Gramnegative bacteria Staphylococcus aureus and Escherichia coli, as well as Condida albicans mushrooms were used, and all the prepared complexes showed higher activity against bacteria and fungus than in the ligand of the free lipid base, and the total antioxidant content of the ligand and the complexes was studied, and the results showed that they have activity as antioxidants compared to tannic acid and gallic acid.