Background: Catheter associated Urinary Tract Infections (CAUTI) is considered as global health concern, leading to the significant morbidity and mortality in the ICU patients. Aim of study: To conduct the surveillance and risk factor analysis of CAUTI patients. Methods: The Prospective cross-sectional study was conducted on 85 patients with indwelling urinary catheter admitted in the ICUs of a tertiary care centre, Gujarat. Further identification of the uropathogens and its Antibiotic susceptibility tests were reported by Vitek -2 Automated systems. Various Risk factors related to both the health care workers and patients were analysed statistically. Results: The CAUTI incidence rate were 12.01/1000 urinary catheter days. Hand Hygiene (P= 0.02, OR-2.245), Periurethral cleaning (P=< 0.0001, OR-3.675), Use of sterile gloves (P=< 0.0001, OR- 2.057), Maintaining Closed drainage system (P = 0.04, OR- 2.057) were significantly associated with the reduction in the rates of CAUTI. Age-group > 50 years (P= 0.04, OR- 1.650) and length of hospital stay > 7 days (P= 0.006, OR- 3.245) significantly upsurges the risk of CAUTI. The most common uropathogens were Escherichia coli (46%) and Klebsiella pneumoniae (19%). Majority of them were Multidrug resistant (MDR). Conclusions: Incidence of CAUTI is higher in the ICU patients, so unvarying surveillance of CAUTI, Stringent infection control practices and antimicrobial stewardship program (ASMP) is the pressing priority.