Oral candidiasis or oral thrush is an infection of the oral cavity most commonly caused by Candida albicans generally occurring secondary to immune suppression. The incidence varies on age and also associated with certain predisposing factors which include salivary gland dysfunction, drugs, dentures, high carbohydrate diet, smoking and diabetes mellitus. Various anti-fungal drugs are available for effective treatment of oral candidiasis. Different conventional oral formulations (Gels, oral solution, suppositories, lozenges, toothpaste, muco-adhesive tablets, tablets, troches, suspensions, pastilles, mouth washes.) for oral candidiasis(OC) are available today. But they have a limited efficacy because of lesser residence time on oral epithelium due to self-cleansing action saliva of oral cavity.Taking into account the high toxicity and the threat of drug resistance of systemic anti-fungal treatment, the Local drug delivery System has been used widely introduced. With local drug administration and controlled drug release of the anti-fungal agents, Drug Delivery system (DDS) could provide higher curative Potential with lesser adverse effects. In this review, we will focus on the application of anti-fungal drugs and oral Biomaterials inspired formulation approaches for the treatment of oral candidiasis.