Recent years have seen an increase in interest in chalcones and compounds derived from them. Chalcones have been the subject of several studies, and their results are encouraging for the development of novel pharmaceuticals. The medicinally significant and beneficial chalcone species contains the flavonoid -CO-CH=CH-, a highly reactive ketoethylenic system. In plants, flavonoids are constructed from chalcones (1, 3-diphenyl-2-propen-1-one). Two or more aromatic rings and a three-carbon ß-unsaturated carbonyl system characterise them. Nevertheless, reports have also surfaced of the synthesis of a wide variety of chalcones in laboratory settings. The pharmacological potencies of chalcone and its derivatives are mainly due to their extremely reactive a, ß-unsaturated carbonyl system. Chalcones and their derivatives have a wide range of pharmacological effects. These effects include anti-inflammatory, antioxidant, antileishmanial, antifungal, anticancer, antibacterial, antiulcer, antiprotozoal, antitumor, antimalarial, antidiabetic, anthelmintic, insecticidal, antitigout, antihistaminic, antiviral, antimycobacterial, and many more positive effects. The synthesis of chalcones can be accomplished in a variety of ways, including the following: one pot synthesis, solvent-free synthesis, ultrasound technique, Aldol condensation, Claisen-Schmidt's condensation, and many more. In this overview, we will look at the different ways chalcones and derivatives can be made, as well as their anti-antioxidant properties.