Background: There are over 700 bacterial species identified in the human oral cavity, of which 400 were located in the periodontal pocket next to the teeth. Besides, bacteremia following dental procedures was found to be a global problem. Methodology: This is a systematic review conducted from December 1, 2020, to January 26, 2021. The databases “PubMed”, “Google Scholar” and “Medline” were searched, and the study included trials investigating the efficiency of mouthwash following dental extraction conducted on the adult population, without restrictions to the year of publication or language. Results were excluded based on stages of title, abstract, and full-text assessments. The risk of bias was assessed using Cochrane’s risk of bias tool. Results: After searching PubMed, Google Scholar and Medline databases, 335 relevant studies were exported to Rayyan application, where duplicates were removed. Eight articles were closely related to the targeted topic and included for the qualitative data synthesis. Conclusion: We found that using 0.2% chlorhexidine (CHX) as a prophylactic mouthwash or as a supplement to habitual oral hygiene against post-extraction bacteremia (PEB) is significantly effective. However, SOS was found to be safer in some cases. Most of the literature reported no significant difference between cetylpyridinium chloride (CPC) and chlorhexidine. Povidone-iodine used as 1% mouthwash was found to be efficient in decreasing the incidence of dry sockets.