Drugs can be generated from many plants. Leucas aspera is known as “Thumbai” were taken and 5g of Leaf was treated with 5ml of ethanol and Acetone respectively, and the flowers of Leucas aspera were also taken. 1g of flower is treated with the 10ml of Ethanol and Acetone each to get the extract. The Antibacterial activity of the extract was found to be in 100 μg/ml of the flower extract of acetone and the maximum antioxidant activity was also found at 120 μg/ml of flower extract of acetone. The GC-MS analysis were done for the identification of bioactive compounds