The Hippo network pathway, which is found in many different species, is crucial for regulating various biological functions such as development, cell growth, stem cell activity, tissue repair, balance within the body, and the size of organs. Over the past two decades, research has revealed the intricate regulation of this pathway by a complex network of molecules inside and outside cells. Disrupting the Hippo network can lead to various diseases, including cancer. There is increasing evidence linking abnormal Hippo network to the formation of tumors, the spread of cancer cells, and resistance to treatment. Monitoring this route has become a viable approach for treating cancer. New drugs that target the Hippo network have shown anti-cancer effects in animal studies and offer hope for cancer patients. However, the exact molecular mechanisms responsible for how Hippo network causes cancer are not fully understood. Scientists are now investigating the involvement of the Hippo network in both the growth of cancer and its resistance to therapy.