Age, epilepsy, and memory have complicated relationships that vary from person to person. Brain disorders such as epilepsy are characterized by frequent, spontaneously recurring seizures. Alternatively, aging is a normal and intricate process that leads to changes in the brain structure and function. Memory can be affected by seizures, and this effect may be more pronounced in people with epilepsy. The degree of memory impairment can vary depending on the type and frequency of seizures, and specific brain regions. Specific memory functions, such as working memory and episodic memory, may deteriorate with age and in epilepsy, which may be evident in electrophysiology and behavioral analysis. Neural connections and the volume of certain brain regions decrease with age, among other brain structural changes that can be detected in immunohistochemistry, histology, biochemical, and molecular studies. It is crucial in improving cognitive defects in aging and epilepsy, especially in old and epileptic animals. Thus, controlling seizure activity in older epileptic animals is essential in improving cognitive function. Cognitive improvement is possible through the use of bioactive compounds, which are often administered to treat seizures. Therefore, investigating the pharmacotherapeutic potential of Hippophae rhamnoides (Seabuckthorn/ Sbt) on cognitive functions, aging, and seizure activity is imperative.