Skin-related diseases are a leading cause of illness and require precise treatment without harming the body. There are a variety of treatments available that have various side effects. Nanotechnology offers advantages like higher therapeutic efficiency, property of drug targeting, and reduction in toxicity. Nanosponges involve porous, spongelike surfaces, and colloidal sizes less than 1 µm in diameter which allows for high loading capacity. Nanosponges are simple to alter the pharmaceutical release contour and enhance formulation stability while reducing the drug's adverse effects. The ability of Nanosponges to self-sterilize is their most notable feature. They are used as anti-allergic, non-mutagenic, and non-irritant in many investigations. In this review, the collection of NSs, with preparation and characterization parameters and applications in various fields is included. This review will be quite useful in the future in exploring the Nanosponge delivery system in different areas.