Introduction: The field of medicine and dentistry has been able to use stem cells and tissue engineering to regenerate damaged tissues. This article finds the progress, challengesand future prospects. Stem Cells: Cells that have the ability to differentiate into various body cells are called stem cells. They primarily divided into two categories: embryonic stem cells ( ESCs) and adult stem cells ( MSCs). Tissue Engineering:Functional tissue production by combining cells, scaffolds and signaling factors, in such a way that the scaffolds provide: a three-dimensional substrate for cell growth. signaling factors cause: differentiation, cell proliferation, and guide path towardsneeded tissues. Empirical approaches:Isolation of stem cells, their cultivation, making a scaffold and culturing cell on it. Results:In tissue engineering, stem cells have a high ability to repair and regenerate tissues, including: cardiac muscle, spinal cord, dental pulp,gingiva, etc. Current limitations:Rejection by immunity, Improper ability in mastery in scaffold integration, ethical concerns (use of embryonic stem cells). Conclusion:Tissue engineering has advanced the medical and dental science by damaged tissue regeneration.Thoughthere are various challenges in this regard, butprogress is going ontofindbettersolutions