In industrialized countries, where human health is threatened by a number of environmental pollutants, particularly heavy metal contaminants, cardiovascular diseases (CVD) are primary public health concerns that are highly widespread. These societies have a high incidence rate1. Our goal was to investigate whether a connection exists between exposure to arsenic and coronary heart disease (CHD). Aim of work: to identify the possible correlation between arsenic exposure and coronary heart disease in a sample of Egyptian population. Patients and methods: All participants (90 participants) 45 cases and 45 control completed a questionnaire about their lifestyle and dietary habits and blood samples were drawn under aseptic conditions to evaluate arsenic blood levels by atomic emission spectroscopy samples collected from cardiology department at Cairo University hospital. Results: This current work demonstrated statistically significant higher levels of arsenic in cases than in control. Arsenic exposure risks were significantly higher in coronary heart disease patients than in control participants. Conclusion: The current work suggested a relation between arsenic blood levels and coronary heart disease.