Background: Unilateral hand clenching is a method that activates the contralateral hemisphere's frontal lobe, potentially enhancing emotional and cognitive processing. While its impact on emotional states is well-documented, its effects on cognition, particularly short-term auditory memory, remain underexplored. This study investigates the influence of hand clenching on short-term auditory memory in young adults. Aim: to investigate the influence of unilateral hand clenching on short-term auditory memory in young adults. Methods: The study included 100 healthy, right-handed first-year MBBS students aged 18-24 years, equally divided by gender. Participants were randomly assigned to five groups based on different hand clenching protocols: no clenching (N/N), right hand clenching before encoding and recall (R/R), right hand clenching before encoding and left-hand clenching before recall (R/L), left hand clenching before encoding and recall (L/L), and left-hand clenching before encoding and right-hand clenching before recall (L/R). Auditory memory was assessed using an Auditory Word Memory (AWM) test, where participants recalled words from audio clips after hand clenching. Results: ANOVA results indicated significant differences in recall performance across hand clenching conditions (F (4, 95) = 6.45, p < 0.05). The R/L group exhibited the highest recall performance, followed by L/L, R/R, L/R, and N/N. Post hoc analysis confirmed the superior performance of the R/L condition compared to other groups. Conclusion: Unilateral hand clenching significantly improves short-term auditory memory in young adults. This technique, particularly right-hand clenching before encoding and left-hand clenching before recall, can be applied to boost cognitive performance, offering practical benefits for learning and memory enhancement.