Gene editing technologies, particularly CRISPR-Cas9, have revolutionized precision medicine by offering unprecedented capabilities in manipulating the genome with high specificity and efficiency. This review article explores the promise of CRISPR-Cas9 in pharmacology, emphasizing its transformative potential. The article begins with an introduction to gene editing, providing a comprehensive overview of CRISPR-Cas9 technology, its historical development, and its mechanism of action involving guide RNA and the Cas9 enzyme.