Severe acute respiratory syndrome-CoV-2 (SARS-CoV-2) virus causes highly contagious condition known as COVID-19 disease which has mild to severe symptoms such as weakness, headache, fever, cough, hypoxia with acute respiratory distress syndrome leadingto multiple organ failure and death. This highly contagious disease is now became the most challenging health problem worldwide. The antibiotics are widely used among hospitalized patients for the management of Covid-19. However a number of studies are still required for the determination of use of antibiotics for the management of Covid-19 patients as significant deaths are reported due to secondary infections and emergence of drug resistant pathogens.Azithromycin is an azalide and very useful for the management of Covid-19 due to its great therapeutic potential. However,there are side effects associated with the use of this antibiotic alone or in combination with other drugs. There are also possible chances of the emergence of antimicrobial resistance among the patients infected with SARS-CoV-2 virus due to the extensive use of antibiotics with threat of transmission of drug resistant pathogens. In this review, the therapeutic potential of azithromycin for the management of Covid-19 patients has been discussed along with clinical evidences about its efficacy alone or in combination with other drugs with possible side effects in the Covid-19 patients.