Grain products have long been a staple of human diets, and more people are beginning to recognize their value as medicinal supplements for the treatment of disease. This chapter examines the historical significance and customary applications of grains and cereals, charting their development from prehistoric civilizations to the present. These food staples are currently at the forefront of research into disease prevention and management due to scientific interest in their nutritional make-up and bioactive components.The basis for the nutritional value of cereals and grains is their macronutrient profile, which includes carbs, proteins, and fats. These elements assist vital biological processes, provide sustained energy release, and improve general health. The micronutrients found in these grains, such as the vitamins and minerals, are also very important. Their wide variety fosters physiological well-being and improves metabolic functions.The substantial dietary fiber content of grains and cereals, which provides digestive advantages, satiety, and cholesterol management, is essential to the therapeutic potential of these foods. Antioxidants, anti-inflammatory drugs, and phytoestrogens are examples of bioactive substances that enhance a substance's ability to combat disease. The chapter dives into particular ways that grains and cereals might be used to prevent and manage diseases, such as heart health, diabetes control, gut flora regulation, and weight management.Additionally, the effects of gluten-containing and non-gluten-containing grains on ailments including celiac disease and gluten sensitivity are investigated. The chapter also discusses recent developments in research, including genetic engineering for improved nutrition, environmentally friendly farming methods, and individualized dietary plans. Actionable insights are provided through the practical integration of cereals and grains into diets, cooking advice, model menus, and disease-specific concerns. The potential of grains and cereals as therapeutic supplements for treating a variety of ailments is highlighted in this chapter's conclusion. It emphasizes their importance as functional foods in supporting health by fusing traditional knowledge with contemporary scientific understanding and provides options for further research.