Objectives:The aim of the current study was to examine the comparison of efficacy and safety of cinnarizine and dimenhydrinate vs Betahistine dihydrochloride and evaluate the psychological distress of vertigo patients.Material and Methods:Over the course of six months, this observational research was conducted at Adesh Hospital in Bathinda on over 160 patients who visited the otorhinolaryngology department, Adesh Institute of Medical Sciences and Research, Adesh Hospital, Bathinda.Results:The patients takingcinnarizine and dimenhydrinatehave reduced symptoms than patients taking betahistine dihydrochloride, combination therapy is more efficient. In terms of safety both drugs are equally safe and patients have mild to moderate psychological distress due to vertigo.Conclusion:This study concluded thatthe patients taking combination therapy has less moderate symptom of vertigo than the patient taking monotherapy which shows that the efficacy of theCinnarizine and Dimenhydrinate is more than the Betahistine dihydrochloride.