Objectives The purpose of this study is to examine Health Quality of Life and determine the frequency of musculoskeletal illnesses associated with job among bank workers. Materials and Methods: 175 purposive sample size was used to choose participants who fit the inclusion criteria and were between the ages of 25 and 50. The Nordic Questionnaire for Musculoskeletal Disorders and the SF-36 for Health Quality of Life were administered to the participants. Results: The study's findings indicated that emotional elements had a stronger correlation with health quality of life, and musculoskeletal issues most frequently affected the lower back. Conclusion: This study revealed that bankers' emotional states had an impact on their physical and mental well-being, with vigorous physical functioning improving these outcomes. The majority of patients had a higher frequency of musculoskeletal problems in the lower back region.