This article primarily highlights Tomato flu (TF), a viral epidemic in India and its characteristics. The causative agent is an RNA virus- a novel variant of Coxsackie virus A16. This is a rare, highly contagious, non-life-threatening disease, observed in children below nine years of age. Patients developed influenza like symptoms and extremely painful rash or blisters, all over the body in the shape of tiny tomatoes, hence the name ‘Tomato Flu’. TF is a clinical subtype of the Hand, Foot, and Mouth Disease. The first suspected case of the current outbreak was reported from Kollam district, Kerala in May 2022 and later spread to other parts of the state and neighbouring states like Odisha, Tamil Nadu, and Haryana in India with hundred plus cases of tomato flu were reported. An in-depth literature search on the viral replication, epidemiological features and classical symptoms of the illness, disease management and preventive, mitigation strategies were carried out. TF being self-limiting, fatal complications were not observed in the affected children. Currently, there are no specific medications available to treat this infection. Hence, symptomatic and supportive therapy were ensured. Vigilant screening, close surveillance, social and personal sanitary measures, and confinement of confirmed or suspected cases must be adopted to prevent further spread. Raising public awareness and promoting proper hand hygiene among children.