The present study aimed to develop and evaluate adhesive patches containing an ethanolic extract of Tinospora cordifolia for the treatment of rheumatoid arthritis. The bark of the plant was used to prepare the extract, which was then incorporated into adhesive patches. The patches were subjected to various tests, including weight variation, thickness, folding endurance, patch area, drug content, moisture content, moisture uptake, in vitro release experiments, ex vivo permeation studies, and stability studies. The prepared adhesive patches were found to be of excellent quality in all the tests performed. The study focused on developing a suitable composition for a transdermal delivery patch that administers a biologically active compound known as Tce to treat arthritis. The Tinospora molecule contains the necessary concentrations of sesquiterpenoids, which are required for effective treatment of the disease. The Tinospora ethanolic extract (TEE), which contains these sesquiterpenoids, inhibits key proinflammatory cytokines, chemokines, mediators of bone remodeling, and matrix degradation, demonstrating antiarthritis activity. The compositions of the patch comprised TEE and release retardants such as ethyl cellulose, polyvinylpyrrolidone (PVP), and propylene glycol. This study presents a new route for the use of herbs that is effective, economical, and enhances therapeutic action while avoiding side effects and toxicity.