The present study aims to explore various dimensions of poisonings alongside psychiatric comorbidities linked to different poisoning scenarios, to improve clinical care practices and inform public health strategies. Methodology: It was a prospective observational study with 123 poisoned patients who have been admitted at Maharaja Institute of Medical Sciences (MIMS) hospital during our study period.Through organized surveys and direct interactions with poisoning victims, the data was acquired. Results: 40(32.5%) were found to be attributed to Pesticide poisoning. In snake poisoning, among 46 cases, 28(22.7%) were reported as hemotoxic, 11(8.9%) as neurotoxic, and 7(8.9%) as unknown. Disinfectant poisoning was observed in 12(9.7%) patients, Drug poisoning in 15(12.1%) patients, and other poisoning cases in 10(8.1%) patients.Pesticide poisoning was more prevalent among patients aged 15-30, suggesting a correlation between age and severity. Conclusion: Snake poisoning cases were the most frequent. Deliberate self-poisoning incidents outnumbered accidental cases. Patients who deliberately poisoned themselves often had psychiatric comorbidities, mainly depressive disorders, linked to couple conflicts and changes in financial status.The statistical data reveals that there is no significant relationship between the severity of the poisoning and the duration from the time of poison exposure to the hospital arrival