Introduction: The prevalence of refractive eye diseases globally has led to increased use of contact lenses (CLs) for corrective, cosmetic, and therapeutic purposes. The rising use of CLs necessitates a comprehensive understanding of awareness levels among non-ophthalmological residents. Objective: This study aimed to assess awareness among non-ophthalmological residents regarding CL use, including indications, types, risks, and hygiene practices. The objective was to identify gaps in knowledge and recommend educational enhancements. Methodology: A cross-sectional study was conducted at a tertiary healthcare center in Tamil Nadu, focusing on residents outside the ophthalmology department. A structured questionnaire covering demographics, CL knowledge, risks, and attitudes was used. Ethical approval was obtained, and confidentiality was ensured. Results: Among 200 participants, 43.5% demonstrated awareness of CL usage. Factors influencing awareness included gender (females more aware, p < 0.001), current users (more aware, p = 0.016), frequency of use (daily users more aware, p = 0.018), and duration of use (> 3 years more aware, p = 0.002). Binomial logistic regression confirmed associations (p < 0.05) with male gender, past CL use, and shorter daily usage periods linked to lower awareness levels. Conclusion: Non-ophthalmological residents exhibit varying levels of awareness regarding CL usage, influenced by gender, usage history, frequency, and duration. Education programs tailored to these factors are crucial for promoting safe and effective CL practices.