Oral cancer is fast becoming one of the major health challenges in India. It has been shown through studies that prevalence of cancer of mouth and tongue taken together exceeds lung cancer. Three cases of oral squamous cell carcinoma (OSCC) that were seen in clinical settings are included in this case series. Every instance has distinct clinical characteristics, difficulties with diagnosis, and treatment modalities. Common features that highlight the need of timely discovery, precise histopathological evaluation, and interdisciplinary cooperation in managing OSCC come to light via these examples. The series also emphasizes how important routine surveillance and follow-up are for preventing illness recurrence and maximizing long-term results. This series adds to the growing understanding of OSCC and educates doctors about the intricacies involved in its diagnosis and treatment by clarifying a variety of clinical presentations and management approaches there by reducing the burden of oral cancer on individuals as well as on society.