Aervasanguinolenta, also referred to as bleeding or bloodleaf Aerva, is a plant used in medicine having a long history of use in traditional medicine. In order to shed light on its possible therapeutic applications, this review examines the phytochemical composition, pharmacological activity, and safety profile of the substance. Its many pharmacological qualities are attributed to the presence of bioactive substances such flavonoids, alkaloids, tannins, and saponins, as shown by the phytochemical study. Because Aervasanguinolenta contains a high concentration of flavonoids and phenolic chemicals, it has been shown to have considerable antioxidant action. Its ability as an antioxidant offers protection against diseases linked to oxidative stress, which makes it a viable option for treating ailments like neurological disorders and cardiovascular disease. Additionally, the plant exhibits strong anti-inflammatory qualities that are mediated through the suppression of pro-inflammatory enzymes and cytokines. Aervasanguinolenta is beneficial because of these anti-inflammatory properties.Aervasanguinolenta emerges as a valuable medicinal plant with diverse pharmacological activities, including antioxidant, anti-inflammatory, antimicrobial, antidiabetic, and anticancer properties. Its safety and toxicity profile underscore its potential as a natural remedy for various ailments, although additional research is needed to fully elucidate its therapeutic potential and ensure its safe use in clinical practice.