Resveratrol is a compound with multiple beneficial properties for oral health, such as its ability to prevent dental caries, reduce gum inflammation and pain, and promote the regeneration of damaged dental tissues. The aim of this work is to describe the use and different clinical applications of resveratrol in dentistry through a systematic review using the PRISMA procedure, for which 19 original articles obtained from the electronic search of the following databases were analyzed: PudMed & Scopus. It is concluded that, the reviewed studies suggest that the use of dental products with resveratrol can be beneficial in several cases, such as the prevention of gingivitis and periodontitis, as well as in the promotion of wound healing, regeneration of dental tissues and improvement in the bonding strength in dental adhesive systems. In general, more research is needed to determine the possible side effects and contraindications of resveratrol use in dentistry.