ISSN : 2663-2187

Validated Dissolution Method For Various Strengths Of Diltiazem Hydrochloride Tablet (Immediate Release) By UV Spectrophotometer.

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Rahul Pandey, Ujjwal Nautiyal, Abhishek Chandola
» doi: 10.33472/AFJBS.6.10.2024.5769-5779

Abstract

The work defines the development of a dissolution method and validation of the method for Diltiazem Hydrochloride tablet immediate release and its various strengths (30, 60, 90, 120mg). The absorption maxima (λmax) of Diltiazem HCl were found to be 237nm. The dissolution media used was water. Various Tablet batches were prepared and the dissolution test was carried out. The batch showing the highest accuracy towards the reference listed drug was finalized and then the method was validated using the finalized batch. The validation protocol was performed as per ICH guideline. The method was found to be cost effective, rugged, linear and precise.

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