Plasmacytosis is a condition of the increased number of plasma cells in tissues, exudate, or blood as a defense mechanism. Transient immune reactions in any infection or autoimmune disorder may present as reactive plasmacytosis that might rarely also manifest as plasma cell mucositis. Reactive plasmacytosis has been reported in several viral infections and has been found to completely disappearwithin 2 weeks. Complete clinical evaluation, individualized investigation, and more specific tests are required to rule out these oral manifestations. Thus, we hereby present an extremely rare condition wherein Human Papillomavirus (HPV) led to reactive plasmacytosis.