Laser refractive surgery is one of the most common eye surgeries worldwide, and it successfully corrects different refractive errors. Aim: the study aimed to compare the refractive outcome of redo by wavefront optimized profile over topography-guided customized ablation profile in residual errors after primary treatment by LASIK or PRK to reach the best visual acuity and least aberration. Methods: This was a prospective comparative randomized clinical study (double-armed) carried out from May 2020 to June 2022. Our final cohort included 36 patients (64 eyes) with variable residual errors after LASIK and PRK who were operated on in Al Rowad Eye Hospital (LASIK and refractive surgery department). Results: a statistically significant difference between pre- and post-topography guided customized ablation as regards OS spherical and OD spherical refractory findings (p-value <0.0001). While there is no significant difference regarding either OS cylindrical or OD cylindrical, there is a statistically significant difference between pre-and post-wavefront optimized profiles as regards OS spherical and OD spherical refractory findings (p-value 0.004 and 0.005, respectively). While there is no significant difference as regards either OS cylindrical or OD cylindrical. Conclusion: Although both topography-guided LASIK and wavefront-optimized LASIK safely and effectively achieved the predicted refractive and visual outcomes, topography-guided LASIK induced fewer HOAs and significantly decreased ocular trefoil, corneal total HOAs, and coma.