As the human body ages, the prevalence of age-related diseases and declination of life span have become significant global issues. Among the many hallmarks of ageing, cellular senescence plays an important role, with senescent cells, often called "zombie cells," accumulating in various tissues and contributing to age-related pathologies and diseases. Cellular senescence is a complex process that involves tissue remodeling and embryogenesis. However, prolonged senescence leads to malignancies and age-related diseases. Cellular senescent cells exhibit histopathological changes like flattened cell shape, granular and vocalizational cytoplasm, and abnormal cell organelles. Therapies targeting senescent cells include senolytic and senomorphic drugs, stem cells, and extra vesicular management, improving life span and reducing inflammation.