The majority of humans interact with animals in various capacities, exposing themselves to the risk of zoonotic diseases, which are illnesses or infections capable of spreading between humans and other vertebrates. Zoonotic diseases originate from a diverse range of pathogens, including bacteria, viruses, fungi, protozoa, and parasites, constituting over 60% of all human diseases. Factors such as urbanization, animal movement, travel, vector biology, and climate change significantly influence the emergence, re-emergence, distribution, and patterns of zoonotic diseases. Human activities, coupled with global trends like urbanization and climate change, have heightened the risks of zoonotic disease transmission, emphasizing the importance of proactive surveillance and interdisciplinary approaches in addressing these complex public health challenges. The hazards to public health, monitoring, and transmission dynamics of zoonotic diseases in animals are examined in this research. We provide a thorough analysis of the methods and strategies used today for zoonotic disease detection in a range of animal populations. The research examines the processes of transmission, focusing on the ways that ecological, environmental, and host-specific variables promote the spread of pathogens from animals to people. We emphasise the implications for public health policies and disease prevention measures by identifying essential sites where human and animal health cross by looking at important case studies and new epidemiological data. In order to reduce the dangers associated with zoonotic illnesses, our findings highlight the significance of coordinated, multidisciplinary approaches to disease surveillance and wildlife management. Preventing future outbreaks and safeguarding the health of humans and animals requires improved surveillance, early diagnosis, and proactive public health actions. The intricate dynamics of zoonotic disease transmission and the requirement for reliable, well-coordinated monitoring systems are better understood as a result of this research.