There are two main parts to the overall issue with plasticizer polymer systems. The degree of achievable miscibility is the primary factor influencing the selection of an appropriate plasticizer for usage with a certain polymer. Plasticizers will then be selected based on their effectiveness in imparting particular qualities, provided that there is adequate miscibility (i.e., a minimal compatibility). The amount of a plasticizer needed to achieve a specific level of plasticity or softness in the plasticizer polymer combination can be used to determine the plasticizer's efficiency. In order to demonstrate how compatibilities can be measured and to quickly discuss the physical reasons that determine good compatibility. The formation of microparticles is at the centre of much research over the last few decades. The physicochemical characteristics of the medication, such as its solubility and chemical stability, influence the choice of an appropriate microparticle formulation method. Modification of the physicochemical properties, including size, shape, morphology, and surface texture, is possible with different ways of manufacturing microparticles. These approaches also impact drug loading, drug entrapment efficiency, and release kinetics. This review covers a comparative study of polymer and solvent nature, the method's toxicity, purification, stability,scalabilityof transdermal patch and information regarding different polymers along with methods used for microparticles formulation techniques.