The global rise in antibiotic resistance has made it necessary to look for alternative treatments because it has compromised the efficacy of conventional antimicrobial therapy. While certain bacteria develop antibiotic resistance spontaneously, antibiotic overuse and the emergence of novel resistant forms through mutation are the main causes of antibiotic resistance in other bacteria. Plants have long been the primary source of medications and complementary therapies for the treatment of illnesses. Valuable secondary metabolites, including flavonoids, terpenoids, quinones, tannins, alkaloids, and polyphenols, are abundant in plants. Plant secondary metabolites are the subject of numerous investigations as a possible source for the development of antibiotics. They can act through a variety of processes and possess the necessary structural qualities. In addition to examining phytochemicals from various classes that have been shown to have antimicrobial activity against resistant bacteria, either on their own or in conjunction with conventional antibiotics, this review examines the antibiotic resistance mechanisms developed by multidrug-resistant bacteria. The current investigation sought to ascertain Swertiachirata's antibacterial efficacy against a number of antibiotic-resistant bacterial pathogens, including Escherichia coli, Pseudomonas aeruginosa, Bacillus species, and Staphylococcus aureus. At a Minimum Inhibitory Concentration (MIC), Swertiachirata demonstrated strong antimicrobial efficacy against a range of antimicrobual resistant bacteria. It might therefore be evolved into a superb broad-spectrum antibacterial agent.