Background: Dengue fever is a significant public health concern, particularly in tropical and subtropical regions. Oxidative stress is known to play a role in the pathophysiology of dengue, contributing to disease severity. Antioxidants such as Vitamin C and Vitamin E have the potential to mitigate oxidative stress and aid in the management of dengue fever. This study aims to evaluate the effect of administering Vitamin C and Vitamin E in patients with dengue fever in a tertiary care center. Aim: To study the effect of administration of Vitamin C and Vitamin E in the management of dengue fever in Shri Sathya Sai Medical College. Materials and Methods:A cross-sectional study was conducted on children aged 5 to 12 years who showed symptoms of dengue fever. The participants were given Vitamin E (7.5-10 mg/day) and Vitamin C supplementation (32 mg/day for ages 4-6, 43 mg/day for ages 7-9, and 54 mg/day for ages 10-12) for one week to assess the effectiveness of these supplements in reducing the symptoms of dengue. All the children had a history of dengue fever and were treated at Shri Sathya Sai Medical College and Research Institute, Ammapettai, Chengalpattu. A total of 60 children received the Vitamin C and E supplements. Key health indicators, including platelet count, WBC count, hemoglobin levels, and packed cell volume, were monitored at different time points from the start of the treatment to day 7. ANOVA analysis was performed using SPSS software to evaluate the significance of the results.