Medicinal plants are the part and parcel of human society to combat against different diseases from the dawn of human civilization. According to World Health Organization, approximately 80% population of the developing countries are facing difficulties to afford synthetic drugs and are relying on traditional medicines mainly of plant origin in order to maintain their primary health care needs. Moringa oleifera LAM (Moringaceae) has been used as traditional medicines in many tropical and subtropical countries. It’s an exceptionally nutritious vegetable with a variety of potential uses in treating rheumatism, venomous bites, and microbial infections. The anti-inflammatory and antipyretic effect of the methanol extract of Moringa oleifera (MEMO) was investigated. The anti-inflammatory effect was studied using Plethysmometer, while the antipyretic effect was estimated using Brewer's yeast-induced hyperpyrexia in rats. The results of the present study revealed that oral administration of MEMO exhibited antipyretic and anti-inflammato¬ry effect in the models studied.