ISSN : 2663-2187

Alcoholic Liver Disease: A Comprehensive Overview, Evaluation, And Management

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Venkata Suresh Jilakara , Dheeraj Berma , Rekha Tarasingh Rajput , Wilson Hrangkhawl , Rakesh Sahebrao Jadhav , Sweety Lanjhiyana , Sanjay Kumar Lanjhiyana , DSVGK Kaladhar , Meesala Sudhakar , Pankaj Gupta, Arpan Kumar Tripathi
ยป doi: 10.48047/AFJBS.6.13.2024.6139-6154

Abstract

Alcoholic liver disease (ALD) refers to a range of disorders that are caused by alcohol-induced metabolic dysfunction in liver cells. ALD starts with steatosis, a condition in which fat builds up in liver cells. It can then advance to alcoholic hepatitis, which is marked by inflammation and the risk of liver failure, and finally lead to permanent alcoholic cirrhosis. The illness etiology is characterized by intricate interplay among genetic, environmental, and immunological variables. From an epidemiological perspective, ALD is a primary contributor to liver-related illness and death worldwide, especially in populations who have long-term and excessive alcohol consumption patterns. The diagnosis is determined by a thorough assessment that combines the patient's medical history, physical examination, laboratory testing, imaging, and occasionally a liver biopsy. The treatment techniques prioritize alcohol abstinence as the core approach, along with providing nutritional assistance and managing consequences such as hepatocellular carcinoma and variceal hemorrhage in advanced stages of cirrhosis. Liver transplantation is an option that might be considered for specific situations of irreparable liver disease. Although recent studies have investigated the use of drugs such as corticosteroids and pentoxifylline to treat severe alcoholic hepatitis, there is still ongoing disagreement over their effectiveness in the long run. In summary, effectively managing ALD requires a collaborative approach from a multidisciplinary healthcare team to enhance patient outcomes, ensure adherence to treatment plans, and deliver comprehensive care that addresses the intricacies of alcohol addiction and its consequences

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