The study analyses the representation of Monkeypox virus (MPXV), an Orthopoxvirus in the Indian online English news reports. The study employed mixed method analysis by employing a combination of qualitative and quantitative approaches. The study evaluates the role of Indian online English news in constructing media narratives for the general public's perception and how it documented this zoonotic illness. The study emphasises the crucial function of media in spreading information during health emergencies and emphasises the necessity for precise, impartial reporting to direct public understanding and policy choices in the convergence of human and animal health.