Sustainable agriculture entails native-adapted rice varieties that are highly nourished and intake limited agricultural inputs. Hassawi and Njavara (Oryza sativa L.) are reddish-brown rice varieties that contain several phytoconstituents, higher than hybrid rice varieties. The present study reveals that there is a higher content of carbohydrates, proteins, glycosides, tannins, saponins, alkaloids and flavonoids present in methanolic extract than in aqueous extract. Other secondary metabolites like, anthraquinones, phenolic compounds, fixed oils and fats, phytosterols and tannins were completely absent in both rice varieties of methanolic and aqueous extracts. Alkaloids are present more in Hasawi than in Njavara rice. Methanolic extracts show more inhibition activity compared to aqueous extracts respectively to the several bacterial species. Obtained results show phytoconstituents of both rice varieties are strongly inhibiting the Bacillus subtilis and Bacillus cereus and Escherichia coli and Pseudomonas aeruginosa growth. Njavara aqueous extract shows a maximum of 19.9 mm (500 ug/ ml) against Bacillus subtilis. But minimum zone of the inhibition 1.9 mm (1 ug/ml)] showed against E.coli. Our preliminary data reveals that Hassawi and Njavara rice varieties contain several phytoconstituents that could play a vital role in human health with huge supplementation of nourishment as a functional food