Chronic kidney disease (CKD) is a growing concern in both developed and developing nations worldwide. This study investigates the impact of cultural, socioeconomic, and health factors on the prevalence and severity of CKD in the Kaviti and Kanchili areas within the Uddanam region of North Coastal Andhra Pradesh, India. A retrospective analysis was conducted on 2,806 participants. Statistical methods, including the Chi-square test, Student's t-test, and Binary Logistic Regression analysis, were employed to assess the associations between selected parameters and CKD. The findings indicate that residing in rural areas and having a lower socio-economic status significantly contribute to the development of CKD. Moreover, patients with CKD are incurring higher medical expenses as the disease progresses. There is an urgent need to improve healthcare facilities, particularly those specializing in kidney diseases, and to raise awareness about CKD risk factors.