Objectives: A study that compared the axillary vein (AV) and subclavian vein (SCV) puncture techniques for permanent pacemaker implantation (PPI). Methods: A cross-sectional, descriptive, prospective study. Here is a summary of the study’s findings in a different way: AV technique is safe and effective for PPI, AV technique may be safer than SCV technique, AV technique resulted in fewer complications than SCV technique at the Vietnam Heart Institute, Bach Mai Hospital from August 2022 to September 2023. Results: A total of 152 patients undergoing PPI were included in the study. Patients were assigned to either the AV group (n=75) or the ACV group (n=77). The overall success rate was similar between the two groups (89.3% vs 93.5%). The number of vein puncture was lower in the AV group (2.7 ± 1.2 vs 3.2 ± 1.6, p < 0.05). The rate of all types of complications was lower in the AV group (9.3%) than in the ACV group (24.7%), p < 0.05. There was no significan difference between the two groups in terms of venous access time, X-ray exposure time, or procedure time (p>0.05). Conclusions: The researchers concluded that the AV access technique is a safe and effective altermative to the SCV access technique for PPI.