One of the most common complications of diabetes is diabetic nephropathy, which is a progressive kidney disease. Large and small sensory fibres are commonly affected by this condition, and it progresses gradually. A "glove and stocking" distribution is followed by the symptoms, which begin in the lower limbs, initially affecting the toes, and then spreading forward in the body. The inability to feel warmth, the inability to sense pain, and the increasing discomfort associated with nephropathy are some of the symptoms that are associated with this condition. Hyperglycemia is the primary source of diabetic nephropathy, according to the primary hypothesis. The condition known as nephropathic pain can be caused by damage to the peripheral nerve system, such as the painful diabetic nephropathy (PDN). Cannabinoids that have a beneficial effect on diabetic nephropathy can be extracted from the ethanolic extract of cannabis sativa. These cannabinoids target the CB1 receptor. When it comes to the treatment of diabetic nephropathic pain, two examples of cannabinoids that have been demonstrated to have therapeutic effects are tetrahydrocannabinol and cannabidol.