This study aims to compare the disintegration properties of natural and synthetic superdisintegrants in mouth-dissolving tablet formulations. The main goal is to determine which superdisintegrant, natural or synthetic, shows better disintegration properties. The study used a mouth-dissolving tablet of rizatriptan benzoate, a novel anti-migraine medication, to create oral dosage forms (ODFs) for migraine treatment. The superdisintegrants used were hibiscus rosa sinensis mucilage, dehydrated banana powder, and crospovidone. The extraction of hibiscus rosa sinensis mucilage and dehydrated banana powder was done by cleaning, grinding, and boiling the leaves. Dehydrated banana powder was extracted by crushing whole bananas into a paste with citric acid and drying them at 50°C. The tablets were then formulated using 2%, 4%, and 6% of these superdisintegrants, along with acacia as a binder, lactose monohydrate as a diluent, magnesium stearate as a flow property enhancer, and saccharin as a sweetening agent. The disintegration time of the tablets decreased with an increase in superdisintegrant concentration. The formulations prepared using natural superdisintegrants showed faster disintegration than synthetic superdisintegrants. The F3 formulation, which contained dehydrated banana powder at a 6% concentration, showed a 45-second disintegration time, less than other formulations. The drug content of all formulations was determined by UV-visible spectroscopy, and the drug content of rizatriptan benzoate was within the Indian Pharmacopeia limit. In an in vitro dissolution study, Formulation F3, which contained dehydrated banana powder at a 6% concentration, showed the best drug release. Natural superdisintegrants Hibiscus rosa sinensis mucilage and dehydrated banana powder showed better disintegration properties than synthetic superdisintegrants like crospovidone. These natural agents are preferred over synthetic substances due to their cost, availability, non- irritating nature, and biodegradability.