This study investigates the formulation and evaluation of a liposomal hydrogel composed of curcumin and Moringa oleifera leaf extract for wound healing. Curcumin, a compound known for its anti-inflammatory and antioxidant properties, and quercetin, an active constituent of moringa leaves with similar properties, were encapsulated in liposomes using the thin film hydration method. The liposomes were incorporated into a carboxymethyl cellulose (CMC) hydrogel matrix. The encapsulation efficiency, particle size, zeta potential, surface morphology, swelling behavior, and release profile of the bioactive compounds were evaluated. The results indicated high encapsulation efficiencies of 88% for curcumin and 93.2% for moringa extract, with sustained release over 24 hours. The formulation showed promising potential for enhancing wound healing through prolonged bioavailability of the active agents and maintaining a moist wound environment.