Artemether, a potent antimalarial drug, suffers from poor aqueous solubility and rapid clearance from the bloodstream, limiting its therapeutic efficacy. Liposomal encapsulation offers a promising strategy to enhance its bioavailability and prolong its circulation time. In this study, we aimed to design nano-sized liposomes encapsulating artemether using the ether injection method and evaluate their physicochemical characteristics and in vitro performance. Liposomes were prepared by hydrating a lipid film composed of phospholipids and cholesterol with an artemether-containing ethanol solution, followed by size reduction using the ether injection technique. The obtained liposomal formulations were characterized for their size, polydispersity index (PDI), zeta potential, drug encapsulation efficiency, and stability. Additionally, the in vitro drug release profile and cytotoxicity against malaria parasites were assessed. The nano-sized liposomes of artemether exhibited a uniform size distribution with an average diameter of [insert size] nm and a low PDI, indicating their homogeneity. The zeta potential measurements revealed [insert charge], suggesting the stability of the liposomal dispersion. Encapsulation efficiency was found to be [insert percentage], demonstrating efficient drug loading within the liposomes. Stability studies demonstrated no significant changes in particle size or drug encapsulation over [insert time period]. In vitro drug release studies exhibited sustained release kinetics, indicating the potential for prolonged drug action. Furthermore, the liposomal formulation showed potent cytotoxicity against malaria parasites, with an IC50 value of [insert value]. In conclusion, nano-sized liposomes prepared by the ether injection method effectively encapsulated artemether, demonstrating favourable physicochemical properties, sustained drug release, and potent antimalarial activity in vitro. These findings suggest the potential of liposomal artemether as a promising formulation for the treatment of malaria, warranting further investigation in animal models and clinical trials.