Background:Seizures are an outcome of an imbalance between excitation and inhibition. GABA is the primary inhibitory neurotransmitter in the central nervous system, and it interacts through GABAA receptors. The hippocampus is a crucial organ in seizure activity, as evidenced by studies that link changes in the expression of the GABAA receptor subunit to seizure activities.Methods:In this study, Wistar rats were split into two groups: one for treatment (diazepam 3 mg/kg BW) and the other for control (no therapy). PTZ (90 mg/kg BW) was used to induce status epilepticus. Thirty minutes after induction, the duration of the seizures was noted. GABAAα1-6 receptor expression was examined by immunohistochemistry in hippocampal brain tissues. One-way ANOVA and linear regression with a significance threshold of p < 0.05 were used to examine the data.Result:Seizures were considerably shorter when diazepam was used than when the control group was involved. The hippocampus's GABAAα1-6 receptor expression was investigated using immunohistochemistry, and the treatment and control groups were shown to differ considerably.Conclusion:The study found a correlation between seizure therapy and seizure duration but not between seizure therapy and GABAA receptors in the cortex, dentate gyrus, or cornu ammonis. IHK analysis showed similar expression in the GABAAα1-6 receptor region in seizure-affected animals, with treatment increasing in all areas. However, the dentate-gyrus region showed the highest expression of diazepam. Further research is needed to determine the appropriate dosage for seizure therapy.