In contemporary educational settings, the effective application of instructional strategies rooted in educational psychology principles is pivotal for optimizing student learning outcomes. This paper delves into the multifaceted landscape of instructional strategies, drawing upon foundational theories from educational psychology to elucidate their efficacy in classroom contexts. Through a comprehensive synthesis of cognitive, behavioral, and constructivist perspectives, this study navigates various instructional methodologies, including differentiated instruction, cooperative learning, inquiry-based learning, direct instruction, and mastery learning. The exploration begins by defining the scope and significance of educational psychology in informing instructional practices. It then proceeds to dissect each instructional strategy, unraveling the underlying theoretical frameworks and elucidating their practical implications for pedagogy. Differentiated instruction, for instance, tailors teaching approaches to accommodate diverse student needs, promoting inclusivity and personalized learning experiences. Cooperative learning harnesses social interaction to foster collaborative problem-solving skills and mutual support among students. Inquiry-based learning cultivates critical thinking and curiosity by empowering students to explore and construct knowledge through self-directed inquiry. Furthermore, this paper examines the role of formative assessment in driving instructional decision-making, emphasizing its value in gauging student progress and identifying areas for targeted intervention. The integration of case studies showcases real-world applications of these instructional strategies, demonstrating their transformative impact on student engagement, motivation, and academic achievement across varied educational contexts. Despite the undeniable benefits of these strategies, challenges persist in their implementation, ranging from resource constraints to addressing the diverse needs and abilities of students. Consequently, educators must navigate these obstacles thoughtfully, leveraging flexible pedagogical approaches and adapting strategies to suit the unique dynamics of their classrooms.