DNA Pol β is essential for DNA repair and maintenance of genomic integrity, its dysregulation or malfunction can contribute to cancer development by increasing mutation rates, promoting genomic instability, and altering cellular signaling pathways. Understanding the role of Pol β in cancer biology may offer insights into novel therapeutic strategies for cancer treatment. The bibliometric analysis using Dimension AI followed by VOSviewer delves into the study of error-prone DNA synthesis and the accumulation of single nucleotide gaps caused by DNA polymerase beta, with a focus on its association with cancer. Since 2020, a substantial increase in publications on this topic has been observed, particularly in 2021, totaling 4821 publications. These include various types such as book chapters, edited books, articles, monographs, preprints, and proceedings, with a total of 9631 publications. Biomedical and Clinical Sciences emerged as the dominant research field with 1702 publications. Co-authorship analysis highlighted Jonkers, Jos as the leading author with 5 documents and 152 citations. The United States led in contributions with 357 documents and 5,396 citations, followed by India with 95 documents and 995 citations. The analysis identified 7 clusters of contributing countries. The International Journal of Molecular Sciences emerged as the most cited source with 37 documents and 762 citations. Harvard University led in co-authorship analysis with 30 documents and 654 citations. Co-citation analysis revealed Hanahan, D, et al. (2011), Jackson, Sp, et al. (2009), and Chatterjee, N, et al. (2017) as top references. The Co-occurrence analysis of terms highlighted 'repair' as the most frequent term, appearing 159 times. Overall, the study provides comprehensive insights into the landscape of research on error-prone DNA synthesis and its implications in cancer, identifying key contributors, sources, and trends in the field.