Background: Epilepsy affects almost 1% of person in world population. Epilepsy has been well controlled by providing the currently available anti-epileptic drugs (AEDs). Most of the anti-epileptic agents present in market have their own side effect and limitations like neurotoxicity and teratogenic effects. Hence there is continuous need for research to find out new or more effective newer AEDs. • Objective :- 1. To evaluate the anticonvulsant activity of Nephelium longan lour peels ethanolic extract in preventing maximal electroshock (MES) and pentylenetetrazole (PTZ) induced convulsions. 2. To compare its efficacy with standard drugs- phenytoin for MES and PTZ method. • Methods:- 48 male albino mice weighing 18-30g are selected and divided into 2 groups of 24 mice each – one group for PTZ and other group for MES method. In PTZ method, seizures were induced in the mice by giving PTZ drug at a dose of 80 mg/kg SC. Each mouse is pre treated with drugs before one hour by giving PTZ. The different groups include – Group C1 administered saline solution (10mg/ kg), Group S1 administered phenytoin (25mg/kg I.P.), Group T1 administered ethanolic extract of Nephelium longan lour peels (200 mg/kg),Group T2 administered ethanolic extract of Nephelium longan lour peels (400mg/kg). In MES method, seizures were induced in the mice via ear clip electrodes with a current of 50 mA for 0.2 seconds. Each mouse is pre treated with drugs (p.o.) before one hour of MES test. The different groups include – Group C2 administered saline solution (10ml/kg), Group S2 administered phenytoin (25mg/kg I.P.), Group T3 administered ethanolic extract of Nephelium longan lour peels (200 mg/kg), Group T4 administered ethanolic extract of Nephelium longan lour peels (400mg/kg).