The study examined the impact of virtual reality (VR)-based interventions on medication adherence for the treatment of chronic non-communicable diseases (NCDs). Patients with NCCD were examined, evaluating sociodemographic variables such as gender, age, educational level, socioeconomic level, professional activity and area of residence, to determine the effectiveness of VR as an intervention tool. The results revealed that 57.10% of patients did not reach an adequate level of compliance with pharmacological treatment. Although the sociodemographic variables studied do not present statistical significance, the area of residence seems to be a determining factor in affiliation. Women were more adherent than men, highlighting the relevance of considering gender-specific approaches in future interventions. In terms of quality of life, patients who were nonadherent to medication reported significantly worse physical health, while those with good mental health showed better medication adherence behaviors. These results highlight the importance of taking both physical and mental health into account in virtual reality-based intervention strategies. In conclusion, virtual reality-based interventions represent a promising alternative to improve treatment adherence in patients with NCD, suggesting the need to adapt these interventions based on the sociodemographic characteristics and specific needs of patients to optimize results. long-term health.