Introduction: Chronic kidney disease (CKD), which is marked by a gradual fall in glomerular filtration rate (GFR), is a significant global public health concern that is linked to high rates of morbidity and death. Methodology: Prospective observational research was conducted for six months. 151 patients' demographics, risk factors, phases, GFR, and medication prescription patterns were gathered using a proforma that was specifically created for this purpose. Results: 151 instances in all were evaluated for the research, with a prevalence of 28.3% female and 72.2% male. The WHO's drug prescribing indicators show that, on average, 12.45 percent of encounters were prescribed; 63.35% of drugs were prescribed by generic name; 86.75% of encounters involved the prescription of an antibiotic; 100% of encounters involved the prescription of an injection; and 73.9% of drugs came from the EML. Conclusion: The study highlights the necessity of focused interventions in CKD patient prescription practices, with an emphasis on utilising cost-effective strategies and managing risk factors. Patient outcomes might be greatly enhanced, and healthcare expenses could be decreased by using customised prescription guidelines and continuous evaluation models.